Associations of urinary di(2-ethylhexyl) phthalate metabolites with lipid profiles among US general adult population

BackgroundDi(2-ethylhexyl) phthalate (DEHP) a parent compound that is metabolized into 4 metabolites, which correlate to adverse cardio-metabolic risk factors. This study aimed explore the links between urinary DEHP metabolites and serum lipids in U.S. general adult population.MethodsIn this cross-sectional study, data on 11 from 2005–2018 National Health Nutrition Examination Surveys (NHANES) were analyzed. Multivariate linear regression restricted cubic spline (RCS) used examine relationship [specific DEHPs: mono-(2-ethyl-5-carboxy-pentyl) (MECPP), mono-(2-ethyl-5-hydroxy-hexyl) (MEHHP), mono-(2-ethylhexyl) (MEHP), mono-(2-ethyl-5-oxo-hexyl) (MEOHP)] (triglycerides [TG], total cholesterol [TC], low-density lipoprotein [LDL-C], high-density [HDL-C]). To identify mixed exposure effects of quantile g-computation (QG-C) weighted sum (WQS) employed for lipid profiles.ResultsA 9141 adults included analysis. MECPP, MEHHP, MEHP, MEOHP highest quartile had negative with HDL-C compared lowest (All P trend <0.05). TG showed significant positive relation <0.05), but there was no notable association MEHP. RCS demonstrated HDL-C, TC, TG, LDL-C (all nonlinearity >0.05). The WQS index independent correlations [β = −0.26, 95%CI (−0.43, −0.09), 0.002], TC 0.55, (0.13, 0.98), 0.011], 2.40, (0.85, 3.96), 0.003].ConclusionOur suggests environmental may affect levels population. Further research warranted confirm these findings illuminate underlying mechanisms lipids.